Carboxylic acids and derivatives
![Medchemexpress LLC 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester | 544450-68-2 | 99.94% | 337.82 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester | 544450-68-2 | 99.94% | 337.82 | 100 MG
COR659 is a potent and effective GABAB positive allosteric modulator (PAM) that suppresses alcohol and chocolate self-administration in rats. Its effects are exerted through a composite mechanism, involving positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.
- Potent and effective GABAB positive allosteric modulator (PAM).
- Suppresses alcohol and chocolate self-administration in rats.
- Exerts effects through a composite mechanism.
- Involves positive allosteric modulation of the GABAB receptor.
- Acts at the cannabinoid CB1 receptor.
- Has shown cytotoxicity against mouse NIH/3T3 cells with an IC50 of 59 μM.
- Relevant to research in neurological, eye or ear disease, neurodegenerative disease, depression, Alzheimer's disease, and Parkinson's disease.
Medchemexpress LLC DiMal-O-CH2COOH | 1620837-47-9 | 96.8% | 308.24 | C13H12N2O7 | 10 MG
This cleavable linker is designed for use in antibody-drug conjugate (ADC) construction and conjugation workflows, offering malemide-based chemistry for attaching payloads to antibodies or targeting moieties. It is provided at research-grade purity and supplied in small quantities suitable for method development and exploratory studies.
- Cleavable linker for ADC construction and conjugation workflows.
- Provides maleimide-based chemistry for reliable payload attachment.
- High purity (96.8%) suitable for research applications.
- Available in small research quantities; larger amounts available on request.
- Store at 4°C, protect from light; in solvent: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Tamoxifen (Citrate) | 54965-24-1 | 99.9% | 563.64 | 1 ML
Tamoxifen Citrate is an orally active, selective estrogen receptor modulator (SERM) that blocks estrogen action in breast cells while activating estrogen activity in other cells like bone, liver, and uterine cells. It functions as a potent Hsp90 activator, enhancing its molecular chaperone ATPase activity. Additionally, it can inhibit infectious EBOV Zaire and Marburg (MARV).
- Selective estrogen receptor modulator
- Blocks estrogen action in breast cells
- Activates estrogen activity in bone, liver, and uterine cells
- Potent Hsp90 activator
- Enhances Hsp90 molecular chaperone ATPase activity
- Inhibits infectious EBOV Zaire and Marburg (MARV)
- Activates autophagy
- Induces apoptosis
- Used to induce gene knockout in CreER transgenic mice
Selleck Chemical LLC Enclomiphene Citrate
Enclomiphene citrate is the trans isomer of clomiphene citrate and acts as a non-steroidal estrogen receptor antagonist
Medchemexpress LLC m-PEG8-CH2COOH | 102013-72-9 | 97.0% | 1 G
m-PEG8-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It has a molecular weight of 442.50 and a molecular formula of C19H38O11. This compound is a colorless to light yellow liquid with a density of 1.122 g/cm3.
- Used in the synthesis of PROTACs.
- Functions as a PEG-based PROTAC linker.
- Facilitates the degradation of target proteins by exploiting the ubiquitin-proteasome system.
- Soluble in DMSO at 200 mg/mL (451.98 mM), with ultrasonic assistance potentially needed.
- Molecular formula: C19H38O11.
- Molecular weight: 442.50.
- Target: PROTAC linkers.
- Pathway: PROTAC.
Medchemexpress LLC Cyclic GMP-AMP diammonium | 96.6% | 708.47 g/mol | C20H30N12O13P2 | 5 MG
cGAMP diammonium is a cyclic dinucleotide that functions as an endogenous second messenger and a potent activator of the stimulator of interferon genes (STING) pathway. Provided as the diammonium salt for research use, it induces type I interferon production and is used to study innate immune signaling.
- Activates STING and triggers type I interferon signaling.
- High purity (96.6%) suitable for research applications.
- Molecular formula C20H30N12O13P2; molecular weight 708.47 g/mol.
- Water-soluble; dissolves up to 100 mg/mL with ultrasonic assistance.
- Solid storage recommended at -20°C; solution storage guidance provided.
- Supplied in small quantities (e.g., 5 mg) for laboratory use.
eMolecules 123-04-6 | 3-(Chloromethyl)heptane | Ambeed | MFCD00018940 | 148.670 | C8H17Cl | 98.000 | CCCCC(CC)CCl | 25g | 599120951
3-(Chloromethyl)heptane | Ambeed | 123-04-6 | MFCD00018940 | 148.670 | C8H17Cl | 98.000 | CCCCC(CC)CCl | 25g | 599120951
Medchemexpress LLC ζ-Stat trisodium (NSC37044 trisodium) | 31894-34-5 | 97.0% | 450.31 | C10H5Na3O10S3 | 50MG
ζ-Stat trisodium is a small-molecule inhibitor of protein kinase C zeta (PKC-ζ) used in biochemical and cellular research. It is supplied as a light yellow to light brown solid with a reported purity of 97.0%, molecular formula C10H5Na3O10S3, and molecular weight 450.31 g/mol. The compound is typically provided in small, preweighed quantities suitable for laboratory studies.
- Inhibits protein kinase C zeta (PKC-ζ) activity.
- CAS number 31894-34-5.
- Purity 97.0%.
- Molecular formula C10H5Na3O10S3; molecular weight 450.31 g/mol.
- Solid, light yellow to light brown appearance.
- Available in multiple small research quantities (mg scale).
Sigma Aldrich Fine Chemicals Biosciences Tris(2-carboxyethyl)phosphine hydrochloride BioUltra, >=98% (NMR) | 51805-45-9 | MFCD00145469 | 10G
Tris(2-carboxyethyl)phosphine hydrochloride BioUltra, >=98% (NMR) | Purity: >=98% (NMR) | Mol Wt: 286.65 | 51805-45-9 | MFCD00145469 | 10G
Medchemexpress LLC Azido-PEG6-CH2COOH | 880129-82-8 | ≥98.0% | 365.38 | 1 G
Azido-PEG6-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is a click chemistry reagent, featuring an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- Functions as a PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Integral to PROTACs that selectively degrade target proteins
Sigma Aldrich Fine Chemicals Biosciences Trisodium citrate dihydrate meets USP testing specifications | 6132-04-3 | MFCD00150031 | 1KG
Trisodium citrate dihydrate meets USP testing specifications | Purity: 99.0-100.5% anhydrous basis | Mol Wt: 294.1 | 6132-04-3 | MFCD00150031 | 1KG